Qihai Gong Selected Research

baohuoside I

1/2020	Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase-3β-mediated activation of autophagy.
3/2019	Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats.
3/2018	Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats.
1/2018	Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats.
1/2018	Icariside II, a PDE5 inhibitor from Epimedium brevicornum, promotes neuron-like pheochromocytoma PC12 cell proliferation via activating NO/cGMP/PKG pathway.
1/2017	Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats.
1/2017	Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.
1/2016	Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats.
1/2016	Icariside II protects against cerebral ischemia-reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation.

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Qihai Gong Research Topics

Disease

12	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2012
8	Neuroinflammatory Diseases 01/2021 - 01/2015
6	Reperfusion Injury 07/2022 - 01/2016
6	Inflammation (Inflammations) 05/2022 - 01/2012
5	Brain Ischemia (Cerebral Ischemia) 07/2022 - 01/2016
5	Infarction (Infarctions) 01/2020 - 01/2012
5	Cognitive Dysfunction 01/2019 - 01/2015
4	Ischemic Stroke 10/2020 - 01/2012
3	Type 2 Diabetes Mellitus (MODY) 05/2022 - 01/2019
3	Stroke (Strokes) 10/2020 - 11/2016
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2020 - 01/2012
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2019 - 01/2017
3	Dementia (Dementias) 01/2018 - 11/2016
3	Neoplasms (Cancer) 01/2017 - 01/2012
2	Fatigue 03/2022 - 01/2022
2	Graves Disease (Basedow Disease) 01/2022 - 01/2022
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2012
2	Ischemia 01/2021 - 10/2020
2	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2020 - 01/2018
2	Memory Disorders (Memory Loss) 01/2019 - 11/2016
2	Amnesia (Dissociative Amnesia) 01/2019 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2016 - 01/2012
2	Brain Injuries (Brain Injury) 01/2016 - 01/2016
1	Chronic Renal Insufficiency 05/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 05/2022
1	Kidney Diseases (Kidney Disease) 05/2022
1	Iron Overload 01/2022
1	Vitamin D Deficiency 01/2022
1	Cardiomegaly (Heart Hypertrophy) 01/2021
1	Hypertrophy 01/2021
1	Hyperplasia 02/2019
1	Lung Neoplasms (Lung Cancer) 02/2019
1	Nausea 02/2019
1	Neutropenia 02/2019
1	Thrombocytopenia (Thrombopenia) 02/2019
1	Vomiting 02/2019
1	Neointima 02/2019
1	Pathologic Constriction (Stenosis) 01/2019
1	Neuroblastoma 12/2018
1	Pheochromocytoma 01/2018

Drug/Important Bio-Agent (IBA)

9	baohuoside IIBA 01/2020 - 01/2016
7	Amyloid beta-PeptidesIBA 01/2020 - 01/2015
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2012
6	Neuroprotective AgentsIBA 10/2020 - 01/2016
3	trilobatinIBA 07/2022 - 10/2020
3	Amyloid (Amyloid Fibrils)IBA 01/2020 - 01/2019
3	Phosphodiesterase 5 InhibitorsIBA 01/2020 - 01/2016
3	icariinIBA 10/2019 - 01/2016
3	FlavonoidsIBA 01/2018 - 01/2016
2	AntioxidantsIBA 03/2022 - 11/2016
2	osthol (osthole)IBA 01/2020 - 01/2012
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 01/2018
2	epimedii flavoneIBA 01/2017 - 01/2016
2	sodium bisulfide (NaHS)IBA 11/2016 - 01/2015
2	Messenger RNA (mRNA)IBA 11/2016 - 01/2012
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 11/2016 - 01/2015
2	Therapeutic UsesIBA 01/2016 - 05/2012
1	urotoxinIBA 05/2022
1	trimethyloxamine (trimethylamine N-oxide)IBA 05/2022
1	PhlorhizinIBA 03/2022
1	Methimazole (Thiamazole)FDA LinkGeneric 01/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Food Additives (Food Additive)IBA 01/2022
1	Protein Kinase CIBA 01/2021
1	Atrial Natriuretic Factor (ANF)IBA 01/2021
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	Natriuretic PeptidesIBA 01/2021
1	ferulic acid (sodium ferulate)IBA 01/2021
1	rhyncophyllineIBA 01/2021
1	Oxygen (Dioxygen)IBA 10/2020
1	Sirtuin 3IBA 10/2020
1	Glucose (Dextrose)FDA LinkGeneric 10/2020
1	Glycogen Synthase (Synthase I)IBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 01/2020
1	InflammasomesIBA 01/2020
1	3-methylamphetamineIBA 01/2020
1	AdipokinesIBA 11/2019
1	GlycolipidsIBA 11/2019
1	LipopolysaccharidesIBA 03/2019
1	GlucosidesIBA 02/2019
1	Biological ProductsIBA 02/2019
1	SodiumIBA 02/2019
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/2019
1	Stem Cell FactorIBA 02/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2019
1	Chemokine CX3CL1IBA 02/2019
1	hydroxide ionIBA 01/2019
1	oxidized low density lipoproteinIBA 01/2019
1	Vitamin D FDA LinkGeneric 01/2019
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2018
1	Oxidants (Oxidizing Agents)IBA 12/2018
1	Ibotenic AcidIBA 03/2018
1	NeurotoxinsIBA 03/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018
1	Docetaxel (Taxotere)FDA Link 01/2018

Therapy/Procedure

3	Therapeutics 01/2021 - 01/2012
3	Drug Therapy (Chemotherapy) 02/2019 - 01/2017
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2019 - 01/2017
1	Percutaneous Coronary Intervention 02/2019